Prognostiske faktorer kan opdeles i<\/p>\n
Prognostiske faktorer kan b\u00e5de anvendes hos patienter med lokal sygdom (forudsige risiko for recidiv), men ligeledes hos patienter med dissemineret sygdom (give et estimat p\u00e5 den mediane overlevelse). Generelt anbefales at anvende TNM og histopatologiske faktorer til lokal sygdom og den kliniske prognostiske model udarbejdet af IMDC til patienter med dissemineret sygdom.<\/p>\n<\/div>\n<\/section>\n<\/div>
Her anvendes TNM-klassifikationen (Se afsnit om anatomisk stadieinddeling af RCC<\/a>). Generelt kan der siges, at jo h\u00f8jere stadium, jo d\u00e5rligere er prognosen.<\/p>\n<\/div>Histopatologiske prognostiske faktorer<\/h4><\/div>Se afsnit om historisk klassifikation af RCC<\/a><\/p>\nHer indg\u00e5r f\u00f8lgende parametre:<\/p>\n\nRCC undertype<\/li>\nWHO og Fuhrman graderingssystem<\/li>\nKarinvasion<\/li>\nTumornekrose<\/li>\nTilstedev\u00e6relse af sarkomatoid\/rhabdoid dedifferentering<\/li>\n<\/ul>\n<\/div>Kliniske prognostiske faktorer<\/h4><\/div>\nPerformance status (PS)<\/a><\/li>\nSymptomer p\u00e5 kr\u00e6ftsygdom<\/li>\nAn\u00e6mi<\/li>\nNeutrofil\/lymfocyt ratio<\/li>\nCRP<\/li>\n<\/ul>\nPrognostiske modeller med inkorporering af flere kliniske faktorer fx IMDC<\/a>,<\/a> som anvendes til at stratificere patienter med dissemineret nyrekr\u00e6ft.<\/p>\n<\/div>Molekyl\u00e6re\/genomiske faktorer<\/h4><\/div>Der er fundet sammenh\u00e6ng mellem flere forskellige mutationer inkl. PBRM1, SETD2, og BAP1 og risiko for recidiv eller d\u00e5rligere overlevelse. Anvendes dog ikke rutinem\u00e6ssigt i klinikken.<\/p>\n<\/div><\/div><\/div><\/div><\/div>Referencer<\/h4><\/div>\nPrognostication in Kidney Cancer: Recent Advances and Future Directions Jeffrey Graham, Shaan Dudani, and Daniel Y.C. Heng<\/em><\/li>\nEuropean Association of Urology. EAU Guidelines on Renal Cell Carcinoma. 2024. Available from: https:\/\/uroweb.org\/guideline\/renal-cell-carcinoma.<\/i><\/li>\nGladell P. Paner, Walter M. Stadler, Donna E. Hansel, Rodolfo Montironi, Daniel W. Lin, Mahul B. Amin, Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers, <\/span>European Urology, <\/span>Volume 73, Issue 4, <\/span>2018, <\/span>Pages 560-569, <\/span>ISSN 0302-2838,<\/span><\/i><\/li>\nDelahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013 Oct;37(10):1490-504. doi: 10.1097\/PAS.0b013e318299f0fb. PMID: 24025520.<\/i><\/li>\n<\/ol>\n<\/div><\/div><\/div>Tjek din viden<\/h4><\/div><\/div><\/div><\/div><\/div>Prognostiske faktorer kan opdeles i:<\/h5><\/div><\/div><\/div><\/div><\/div><\/div><\/div>Anatomiske, Histopatologiske, Kliniske<\/label><\/div>Histopatologiske, Anatomiske, Molekyl\u00e6re\/genomiske<\/label><\/div>Anatomiske, Histopatologiske, Kliniske, Molekyl\u00e6re\/genomiske<\/label><\/div><\/fieldset><\/div>(Det er helt anonymt at bruge quiz'en!)<\/small><\/p>\n<\/div><\/div><\/div><\/i><\/div>\n<\/div>Svaret er korrekt!<\/p>\n<\/div><\/i><\/div><\/p>\n<\/div>Svaret er forkert!<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/form><\/div>Forts\u00e6t til n\u00e6ste afsnit: 3.1 Behandlingsalgoritme<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span>Udforsk denne kapitelmenu<\/h5><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div>2.1 Symptomer p\u00e5 nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.2 Udredning ved mistanke om nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.3 Multidisciplin\u00e6r Team (MDT) konference<\/span><\/i><\/a><\/div>2.4 Prognostiske stratificeringsv\u00e6rkt\u00f8jer til patienter med mRCC<\/span><\/i><\/a><\/div>2.5 Prognostiske faktorer<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":7487,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-7507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":15,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions"}],"predecessor-version":[{"id":12006,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions\/12006"}],"up":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7487"}],"wp:attachment":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/media?parent=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Se afsnit om historisk klassifikation af RCC<\/a><\/p>\nHer indg\u00e5r f\u00f8lgende parametre:<\/p>\n\nRCC undertype<\/li>\nWHO og Fuhrman graderingssystem<\/li>\nKarinvasion<\/li>\nTumornekrose<\/li>\nTilstedev\u00e6relse af sarkomatoid\/rhabdoid dedifferentering<\/li>\n<\/ul>\n<\/div>Kliniske prognostiske faktorer<\/h4><\/div>\nPerformance status (PS)<\/a><\/li>\nSymptomer p\u00e5 kr\u00e6ftsygdom<\/li>\nAn\u00e6mi<\/li>\nNeutrofil\/lymfocyt ratio<\/li>\nCRP<\/li>\n<\/ul>\nPrognostiske modeller med inkorporering af flere kliniske faktorer fx IMDC<\/a>,<\/a> som anvendes til at stratificere patienter med dissemineret nyrekr\u00e6ft.<\/p>\n<\/div>Molekyl\u00e6re\/genomiske faktorer<\/h4><\/div>Der er fundet sammenh\u00e6ng mellem flere forskellige mutationer inkl. PBRM1, SETD2, og BAP1 og risiko for recidiv eller d\u00e5rligere overlevelse. Anvendes dog ikke rutinem\u00e6ssigt i klinikken.<\/p>\n<\/div><\/div><\/div><\/div><\/div>Referencer<\/h4><\/div>\nPrognostication in Kidney Cancer: Recent Advances and Future Directions Jeffrey Graham, Shaan Dudani, and Daniel Y.C. Heng<\/em><\/li>\nEuropean Association of Urology. EAU Guidelines on Renal Cell Carcinoma. 2024. Available from: https:\/\/uroweb.org\/guideline\/renal-cell-carcinoma.<\/i><\/li>\nGladell P. Paner, Walter M. Stadler, Donna E. Hansel, Rodolfo Montironi, Daniel W. Lin, Mahul B. Amin, Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers, <\/span>European Urology, <\/span>Volume 73, Issue 4, <\/span>2018, <\/span>Pages 560-569, <\/span>ISSN 0302-2838,<\/span><\/i><\/li>\nDelahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013 Oct;37(10):1490-504. doi: 10.1097\/PAS.0b013e318299f0fb. PMID: 24025520.<\/i><\/li>\n<\/ol>\n<\/div><\/div><\/div>Tjek din viden<\/h4><\/div><\/div><\/div><\/div><\/div>Prognostiske faktorer kan opdeles i:<\/h5><\/div><\/div><\/div><\/div><\/div><\/div><\/div>Anatomiske, Histopatologiske, Kliniske<\/label><\/div>Histopatologiske, Anatomiske, Molekyl\u00e6re\/genomiske<\/label><\/div>Anatomiske, Histopatologiske, Kliniske, Molekyl\u00e6re\/genomiske<\/label><\/div><\/fieldset><\/div>(Det er helt anonymt at bruge quiz'en!)<\/small><\/p>\n<\/div><\/div><\/div><\/i><\/div>\n<\/div>Svaret er korrekt!<\/p>\n<\/div><\/i><\/div><\/p>\n<\/div>Svaret er forkert!<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/form><\/div>Forts\u00e6t til n\u00e6ste afsnit: 3.1 Behandlingsalgoritme<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span>Udforsk denne kapitelmenu<\/h5><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div>2.1 Symptomer p\u00e5 nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.2 Udredning ved mistanke om nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.3 Multidisciplin\u00e6r Team (MDT) konference<\/span><\/i><\/a><\/div>2.4 Prognostiske stratificeringsv\u00e6rkt\u00f8jer til patienter med mRCC<\/span><\/i><\/a><\/div>2.5 Prognostiske faktorer<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":7487,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-7507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":15,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions"}],"predecessor-version":[{"id":12006,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions\/12006"}],"up":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7487"}],"wp:attachment":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/media?parent=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Her indg\u00e5r f\u00f8lgende parametre:<\/p>\n
Prognostiske modeller med inkorporering af flere kliniske faktorer fx IMDC<\/a>,<\/a> som anvendes til at stratificere patienter med dissemineret nyrekr\u00e6ft.<\/p>\n<\/div>Molekyl\u00e6re\/genomiske faktorer<\/h4><\/div>Der er fundet sammenh\u00e6ng mellem flere forskellige mutationer inkl. PBRM1, SETD2, og BAP1 og risiko for recidiv eller d\u00e5rligere overlevelse. Anvendes dog ikke rutinem\u00e6ssigt i klinikken.<\/p>\n<\/div><\/div><\/div><\/div><\/div>Referencer<\/h4><\/div>\nPrognostication in Kidney Cancer: Recent Advances and Future Directions Jeffrey Graham, Shaan Dudani, and Daniel Y.C. Heng<\/em><\/li>\nEuropean Association of Urology. EAU Guidelines on Renal Cell Carcinoma. 2024. Available from: https:\/\/uroweb.org\/guideline\/renal-cell-carcinoma.<\/i><\/li>\nGladell P. Paner, Walter M. Stadler, Donna E. Hansel, Rodolfo Montironi, Daniel W. Lin, Mahul B. Amin, Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers, <\/span>European Urology, <\/span>Volume 73, Issue 4, <\/span>2018, <\/span>Pages 560-569, <\/span>ISSN 0302-2838,<\/span><\/i><\/li>\nDelahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013 Oct;37(10):1490-504. doi: 10.1097\/PAS.0b013e318299f0fb. PMID: 24025520.<\/i><\/li>\n<\/ol>\n<\/div><\/div><\/div>Tjek din viden<\/h4><\/div><\/div><\/div><\/div><\/div>Prognostiske faktorer kan opdeles i:<\/h5><\/div><\/div><\/div><\/div><\/div><\/div><\/div>Anatomiske, Histopatologiske, Kliniske<\/label><\/div>Histopatologiske, Anatomiske, Molekyl\u00e6re\/genomiske<\/label><\/div>Anatomiske, Histopatologiske, Kliniske, Molekyl\u00e6re\/genomiske<\/label><\/div><\/fieldset><\/div>(Det er helt anonymt at bruge quiz'en!)<\/small><\/p>\n<\/div><\/div><\/div><\/i><\/div>\n<\/div>Svaret er korrekt!<\/p>\n<\/div><\/i><\/div><\/p>\n<\/div>Svaret er forkert!<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/form><\/div>Forts\u00e6t til n\u00e6ste afsnit: 3.1 Behandlingsalgoritme<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span>Udforsk denne kapitelmenu<\/h5><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div>2.1 Symptomer p\u00e5 nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.2 Udredning ved mistanke om nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.3 Multidisciplin\u00e6r Team (MDT) konference<\/span><\/i><\/a><\/div>2.4 Prognostiske stratificeringsv\u00e6rkt\u00f8jer til patienter med mRCC<\/span><\/i><\/a><\/div>2.5 Prognostiske faktorer<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":7487,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-7507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":15,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions"}],"predecessor-version":[{"id":12006,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions\/12006"}],"up":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7487"}],"wp:attachment":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/media?parent=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Der er fundet sammenh\u00e6ng mellem flere forskellige mutationer inkl. PBRM1, SETD2, og BAP1 og risiko for recidiv eller d\u00e5rligere overlevelse. Anvendes dog ikke rutinem\u00e6ssigt i klinikken.<\/p>\n<\/div><\/div><\/div><\/div><\/div>
(Det er helt anonymt at bruge quiz'en!)<\/small><\/p>\n<\/div><\/div><\/div><\/i><\/div>\n<\/div>Svaret er korrekt!<\/p>\n<\/div><\/i><\/div><\/p>\n<\/div>Svaret er forkert!<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/form><\/div>Forts\u00e6t til n\u00e6ste afsnit: 3.1 Behandlingsalgoritme<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span>Udforsk denne kapitelmenu<\/h5><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div>2.1 Symptomer p\u00e5 nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.2 Udredning ved mistanke om nyrekr\u00e6ft<\/span><\/i><\/a><\/div>2.3 Multidisciplin\u00e6r Team (MDT) konference<\/span><\/i><\/a><\/div>2.4 Prognostiske stratificeringsv\u00e6rkt\u00f8jer til patienter med mRCC<\/span><\/i><\/a><\/div>2.5 Prognostiske faktorer<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":7487,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-7507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":15,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions"}],"predecessor-version":[{"id":12006,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7507\/revisions\/12006"}],"up":[{"embeddable":true,"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/pages\/7487"}],"wp:attachment":[{"href":"https:\/\/d1s07skqdwll4z.cloudfront.net\/da\/wp-json\/wp\/v2\/media?parent=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Svaret er korrekt!<\/p>\n<\/div>
Svaret er forkert!<\/p>\n<\/div>\n<\/div><\/div>