Grade 1:
Hb: LLN-6.2 mmol/L
Thrombocytes
Neutrophils <LNN-1,5 E9/l

Grade 1:
Maintain TKI dose.

–

Grade 2:
Hb: 6.2–4.9 mmol/L
Thrombocytes <75–50 E9/L
Neutrofils <1.5-1 E9/L

Grade 2:
Maintain TKI dose.

Grade 2:
In the event of bleeding from mucous membranes or skin or if feverish (> 38.5), advise the patient to contact the department. Check haematology after 14 days.

Grade 3:
Hb: 4.9–4 mmol/L
Thrombocytes <50–10 E9/L
Neutrophils <1–0.5 E9/L

Grade 3:
1) Pause TKI.
2) Check haematology weekly.
3) Resume TKI at reduced dose at grade ≤ 2 and check haematology weekly.

Grade 3:
See above.
If low Hb, consider bleeding, haemolysis.
In the event of bleeding, a thrombocyte infusion should be given and other AC treatment should be paused.
In the event of fever, the patient must be admitted and treated in accordance with febrile neutropenia regimen.

Grade 4:
Hb <4 mmol/L Thrombocytes <10 E9/L Neutrophils <0.5 E9/L

Grade 4:
1) Pause TKI.
2) See under grade 3.

Grade 4:
For grade 4 anaemia or thrombocytopenia, the patient should be admitted for blood and thrombocyte infusion.